Panel casts doubt on helium sell-off plan

Re-evaluation casts doubt on the pathogenicity of homozygous USH2A p.C759F.

Mutations in USH2A are a common cause of Retinitis Pigmentosa (RP). Among the most frequently reported USH2A variants, c.2276G>T (p.C759F) has been found in both affected and healthy individuals. The pathogenicity of this variant remains controversial since it was detected in homozygosity in two healthy siblings of a Spanish family (S23), eleven years ago. The fact that these individuals remain...

When one model casts doubt on another: a levels-of-analysis approach to causal discounting.

Discounting is a phenomenon in causal reasoning in which the presence of one cause casts doubt on another. We provide a survey of the descriptive and formal models that attempt to explain the discounting process and summarize what current models do not account for and where room for improvement exists. We propose a levels-of-analysis framework organized around 2 types of models of causal discou...

Purification of Maize Nucleotide Pyrophosphatase/Phosphodiesterase Casts Doubt on the Existence of Zeatin Cis–Trans Isomerase in Plants

Almost 25 years ago, an enzyme named zeatin cis-trans isomerase from common bean has been described by Bassil et al. (1993). The partially purified enzyme required an external addition of FAD and dithiothreitol for the conversion of cis-zeatin to its trans- isomer that occurred only under light. Although an existence of this important enzyme involved in the metabolism of plant hormones cytokini...

Testing the Toxicofera : comparative reptile transcriptomics casts doubt on the single , early 4 evolution of the reptile venom system

Hla-cspif Panel on Commercial Off-the-shelf Distributed Simulation

Commercial-off-the-shelf (COTS) simulation packages are widely used in many areas of industry. Several research groups are attempting to integrate distributed simulation principles and techniques with these packages to potentially give us COTS distributed simulation. The High Level Architecture – COTS Simulation Package Interoperation Forum (HLA-CSPIF) is a group of researchers and practitioner...